College of Agriculture & Natural Resources
Department of Veterinary Medicine

Georgiy (George) Belov

PhD Associate Professor

E-mail:gbelov@umd.edu
Phone:301-314-1259
Fax:301-314-6855

 

 

 

 

Dr. Belov Lab:  Postdoctoral and Graduate Students

 

 

 

Education and Professional Experience

  • 2010-present Associate professor. VA-MD Regional College of Veterinary Medicine, University of Maryland
  • 2002-2010 Postdoctoral research fellow. National Institute of Allergy and Infectious Diseases, National Institutes of Health, USA
  • 2000-2002 Postdoctoral research associate. M. P. Chumakov Institute of Poliomyelitis and Viral Encephalitides, Moscow, Russia
  • 2001 PhD. Virology. M. V. Lomonosov Moscow State University. Moscow, Russia
  • 1992 MSc Biology (with honors) M. V. Lomonosov Moscow State University, Moscow, Russia
  
  

Current Research Topics

  • Understanding molecular mechanisms of membrane remodeling in cells infected with positive strand RNA viruses
  • Characterization of the role of cellular Arf GEF proteins in replication of picornaviruses
  • Development of novel anti-viral therapeutics targeting cellular factors hijacked for viral replication

  Increased membrane synthesis in a poliovirus-infected Vero cell

Above:  Increased membrane synthesis in a poliovirus-infected Vero cell (arrow)

   

Publications

  • Belov GA and van Kuppeveld FJM. (+)RNA viruses rewire cellular pathways to build replication organelles. Curr Opin Virol., 2012 Dec;2(6):740-7
  • Belov GA, Nair V, Hanssen B, Hoyt F, Fischer E and Ehrenfeld E. Complex Dynamic Development of Poliovirus Membranous Replication Complexes. J. Virol. 2012. 86(1):302-12
  • Belov GA, Kovtunovych G, Jackson CL, and Ehrenfeld E. Poliovirus Replication Requires the N-terminal Portion but not the Catalytic Sec7 Domain of Cellular Arf Activator GBF1. Cell. Microbiol. 2010 May. DOI: 10.1111/j.1462-5822.2010.01482.x
  • Nai-Yun H, Ilnytska O, Belov G, Santiana M, Ying-Han C, Kaushik-Basu N, Balla T, Ehrenfeld E, van Kuppeveld F, and Altan-Bonnet N. Viruses reorganize secretory pathway to form organelles with specific lipid microenvironment for RNA replication Cell. 2010;141(5):799-811
  • Lanke, KH, van der Schaar, HM, Belov GA, Feng Q, Duijsings,D, Jackson CL, Ehrenfeld E. van Kuppeveld, F. J. GBF1, a guanine nucleotide exchange factor for Arf, is crucial for coxsackievirus B3 RNA replication. J Virol 2009 83,11940-9
  • Belov GA, Feng Q, Nicovics K, Jackson CL and Ehrenfeld E. A Critical Role of a Cellular Membrane Traffic Protein in Poliovirus RNA Replication. PLoS Pathogens 20084 (11)e1000216

 

3D reconstruction of poliovirus membranous replication organelles 

Above:
 3D reconstruction of poliovirus membranous replication organelles

Below: A HeLa cell infected with poliovirus at 8 hours post infection

 A HeLa cell infected with poliovirus at 8 hours post infection

 

 

 

 

 

 

 

 

 

 

 

 





 

 

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