College of Agriculture & Natural Resources
Department of Veterinary Medicine

Meiqing Shi

Meiqing Shi

DVM, PhD Associate Professor

E-mail:mshi@umd.edu
Phone:301 314-1122
Fax:301-314-6855
  

 

 

 

Professional Experience

  • 2017 Associate Professor, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland
  • 2011 Assistant Professor, Virginia-Maryland Regional College of Veterinary Medicine, University of Maryland, College Park, Maryland
  • 2006 Research Associate, Faculty of Medicine, University of Calgary, Calgary, Canada
  • 2000 Postdoctoral Fellow, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada
  • 2000 Ph.D. Immunology, Faculty of Veterinary Medicine, Justus Liebig University of Giessen, Germany
  • 1990 Lecturer, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
  • 1988 M.S. Avian Medicine, South China Agricultural University, Guangzhou, China
  • 1985 D.V.M. Veterinary Medicine, Hunan Agricultural University, Changsha, China

 

 

 

Current Research Topics

  • Intravascular immune responses to Cryptococcus neoformans and Trypanosoma brucei
  • Molecular mechanisms involved in brain invasion by C. neoformans and T. brucei
  • Dynamic interactions of immune cells with C. neoformans and T. brucei in the brain
  • Role of T cells and cytokines in the immunopathogenesis of trypanosome infections

 

Above: Intravital imaging of Ito cells (green) surrounding liver sinusoids (blue)

Publications

  • Shi, M., Calaruso, P. & Mody, C.H. (2012) Real-time in vivo imaging of fungal migration to the CNS. Cellular Microbiology, 14(12):1819-1827. Evaluated by Faculty of 1000 Biology.

  • Moriarty, T.J., Shi, M., Lin, Y.P., Ebady, R., Zhou, H., Odisho, T., Hardy, P.O., Salman-Dilgimen, A., Wu, J., Weening, E.H., Skare, J.T., Kubes, P., Leong, J., & Chaconas, G. (2012) Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules. Molecular Microbiology, 86(5):1116-1131.

  • Shi, M., Wang, A., Prescott, D., Waterhouse, C., Zhang, S., McDougall, J.J., Sharkey, K.A. & McKay, D.M. Infection with an intestinal helminth parasite reduces Freund’s complete adjuvant-induced mono-arthritis in mice. Arthritis & Rheumatism, 2011; 63: 434-444.
  • Shi, M., Li, S.S., Zheng, C.F., Jones, G.J., Kim, K.S., Zhou, Z., Kubes, P. & Mody, C.H. Real-time imaging of trapping and urease-dependent transmigration of Cryptococcus neoformans in mouse brain. Journal of Clinical Investigation, 2010; 120: 1683-1693. Evaluated by Faculty of 1000 Biology.

  • Ye, Z., Shi, M., Xu, S. & Xiang, J. LFA-1 defect-induced effector/memory CD8+ T cell apoptosis is mediated via Bcl-2/Caspase pathways and associated with downregulation of CD27 and IL-15R. Molecular Immunology, 2010; 47: 2411-2421.

 

 

Top: C. neoformans (red) was penetrating the brain vessel wall (green)

Center: A 3D image shows the trapping of C. neoformans (red) in the brain capillaries (green)

Bottom: C. neoformans cells (green) were arrested in the brain capillaries (red)

 

 

 

 

 

 

 

 

 





 

 

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