College of Agriculture & Natural Resources
Department of Veterinary Medicine

Yanjin Zhang

Yanjin Zhang


Associate Professor

E-mail: zhangyj@umd.edu
Phone: 301-314-6596
Fax: 301-314-6855
Lab: 301-314-9615

 

 

 

Professional Experience

  • 2012 Associate Professor, VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, MD
  • 2005 Assistant Professor, VA-MD Regional College of Veterinary Medicine, University of Maryland, College Park, MD
  • 2002 Assistant Professor, Center for Pediatric Research, Eastern Virginia Medical School, Norfolk, VA
  • 2001 Instructor, The University of Texas Health Science Center at San Antonio, San Antonio, TX
  • 1998 Postdoctoral Fellow, The University of Texas Health Science Center at San Antonio, San Antonio, TX
  • 1998 Ph.D, Immunobiology, Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, IA
  • 1989 M.S., Microbiology & Immunology, The National Control Institute of Veterinary Bioproducts and Pharmaceuticals, China
  • 1984 DVM, Veterinary Medicine, Shandong Agricultural University, China

 



Current Research Topics

  • Molecular virology of hepatits E virus (HEV) and porcine reproductive and respiratory syndrome virus (PRRSV)
  • Virus-cell interactions of HEV and PRRSV
  • Molecular pathogenesis of HEV and PRRSV
  • Vaccine development

 

Above: HEV Virion

Publications

  • L. Yang and Y. Zhang. Antagonizing Cytokine-Mediated JAK-STAT Signaling by Porcine Reproductive and Respiratory Syndrome Virus. For a special issue in Veterinary Microbiology 2017. http://dx.doi.org/10.1016/j.vetmic.2016.12.036. Review. Epub ahead of print.
  • L. Yang, R. Wang, Z. Ma, Y. Xiao, Y. Nan, Y. Wang, S. Lin, and Y. Zhang: Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via Inducing STAT3 Degradation. Journal of Virology 2017, 91:e02087-16. https://doi.org/10.1128/JVI.02087-16.
  • E. Fontanella, Z. Ma, Y. Zhang, A. Castro, H. Shen, P.G. Halbur, T. Opriessnig: An interferon inducing porcine reproductive and respiratory syndrome virus vaccine candidate elicits protection against challenge with a heterologous virulent type 2 strain in pigs. Vaccine. 2017 Jan 3;35(1):125-131.
  • R. Wang, Y. Zhang, Y. Lin, X. Yang, L. Bai, Y. Chen, S. Zhao, X. Cheng, and E. Liu: Protein Inhibitor of Activated STAT3 Suppresses Oxidized LDL-Induced Cell Responses during Atherosclerosis in Apolipoprotein E Deficient Mice. Scientific Reports 2016 Nov 15;6:36790. doi: 10.1038/srep36790.
  • Z. Ma, Y. Yu, Y. Xiao, T. Opriessnig, R. Wang, L. Yang, Y. Nan, S. Samal, P. Halbur, and Y. Zhang: Sustaining Interferon Induction by a High-Passage Atypical Porcine Reproductive and Respiratory Syndrome Virus Strain. Scientific Reports 2016 Nov 2;6:36312; doi: 10.1038/srep36312 (2016).
  • Y. Nan and Y. Zhang: Molecular Biology and Infection of Hepatitis E Virus. Frontiers in Microbiology 2016, 7:1419; doi: 10.3389/fmicb.2016.01419. Review.
  • Y. Yang, Y. Nan, Z. Ma, L. Yang, and Y. Zhang: A Linear Surface Epitope in a Proline-Rich Region of ORF3 Product of Genotype 1 Hepatitis E Virus. Viruses 2016, 8, 227; doi:10.3390/v8080227.
  • Y. Xiao, Z. Ma, R. Wang, L. Yang, Y. Nan, and Y. Zhang: Downregulation of Protein Kinase PKR Activation by Porcine Reproductive and Respiratory Syndrome Virus at Its Early Stage Infection. Veterinary Microbiology 2016, 187, 1, 1-7. DOI: 10.1016/j.vetmic.2016.03.004.
  • L. Yang, R. Wang, Z. Ma, Y. Wang, and Y. Zhang. Inducing Autophagic Cell Death by nsp5 of Porcine Reproductive and Respiratory Syndrome Virus. Austin Virol and Retrovirology. 2015; 2(2): 1-4.
  • Y. Nan, Z. Ma, H. Kannan, D.A. Stein, P.I. Iversen, X-J. Meng, and Y. Zhang: Inhibition of hepatitis E virus replication by peptide-conjugated morpholino oligomers. Antiviral Research 2015, 120, 134-139.
  • C. Wu, Y. Nan and Y. Zhang: New insights into hepatitis E virus virus–host interaction: interplay with host interferon induction. Future Virology 2015,10(4), 439–448. Review.
  • Y. Nan, G. Nan, and Y. Zhang: Interferon Induction by RNA Viruses and Antagonism by Viral Pathogens. Viruses 2014 Dec 12;6(12):4999-5027. Review.
  • Y. Nan, Ying Yu, Z. Ma, Brenda Fredericksen, and Y. Zhang: Hepatitis E virus Inhibits Interferon Induction by ORF1 Product. Journal of Virology 2014. 88:20:11924-11932. Epub Aug 6, 2014.
  • J. Butler, K. M. Lager, W. Golde, K. S. Faaberg, M. Sinkora, C. Loving, and Y. Zhang: Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic. Immunologic Research. 2014 Aug;59(1-3):81-108. doi: 10.1007/s12026-014-8549-5. Published online on July 1, 2014.
  • 1. Luo, A., Y. Yang, Y. Yu, Y. Xiao, and Y. Zhang: Enhancing Solubilization of Hydrophobic ORF3 Product of Hepatitis E Virus in Bacterial Expression System. Journal of Vaccine and Immunotechnology. 2014;1(1): 5
  • R. Wang and Y. Zhang: Antagonizing Interferon-Mediated Immune Response by Porcine Reproductive and Respiratory Syndrome Virus. BioMed Research International 2014;2014:315470. Epub 2014 Jul 3.
  • Y. Nan, Z. Ma, Rong Wang, Ying Yu, and Y. Zhang: Enhancement of interferon induction by ORF3 product of hepatitis E virus. Journal of Virology 2014. 88:15:8696-8705. Epub May 21, 2014. PMID: 24850742.
  • P.D. Burbelo, J.A. Ragheb, A. Kapoor, and Y. Zhang: The Serological Evidence in Humans Support a Negligible Risk of Zoonotic Infection from Porcine Circovirus Type 2. Biologicals 41:6:430-434. doi: 10.1016/j.biologicals.2013.09.005. Epub 2013 Oct 10. PMID: 24120888.
  • Wang R, Xiao Y, Opriessnig T, Ding Y, Yu Y, Nan Y, Ma Z, Halbur PG, Zhang YJ: Enhancing neutralizing antibody production by an interferon-inducing porcine reproductive and respiratory syndrome virus strain. Vaccine 2013. 31:5537-5543. doi: 10.1016/j.vaccine.2013.09.023. Epub 2013 Sep 21. PMID: 24063978.
  • R. Wang, Y. Nan, Y. Yu, Z. Yang, and Y. Zhang: Variable interference with interferon signal transduction by different PRRSV strains. Vet Microbiology 2013. 166:493-503. doi: 10.1016/j.vetmic.2013.07.022. PMID: 23953026.
  • Yu Y, Wang R, Nan Y, Zhang L, Zhang Y: Induction of STAT1 Phosphorylation at Serine 727 and Expression of Proinflammatory Cytokines by Porcine Reproductive and Respiratory Syndrome Virus. PLoS ONE 2013. 8(4): e61967. doi:10.1371/journal.pone.0061967. PMID: 23637938.
  • R. Wang, Y. Nan, Ying Yu, and Y. Zhang: Porcine Reproductive and Respiratory Syndrome Virus Nsp1β Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin-α1 Degradation. Journal of Virology 2013. 87(9):5219. DOI: 10.1128/JVI.02643-12. Pubmed PMID: 23449802.
  • Y. Nan, Rong Wang, M. Shen, Kay S. Faaberg, S.K. Samal, and Y. Zhang: Induction of Type I Interferons by a Novel Porcine Reproductive and Respiratory Syndrome Virus Isolate. Virology 2012;432:261-270. DOI: 10.1016/j.virol.2012.05.015. Pubmed PMID: 22704065
  • K. Ritthipichai, Y. Nan, I. Bossis, Y. Zhang: Viral FLICE Inhibitory Protein of Rhesus Monkey Rhadinovirus Inhibits Apoptosis by Enhancing Autophagosome Formation. PLoS ONE 2012; 7(6): e39438. doi:10.1371/journal.pone.0039438. PMID: 22745754.
  • Y. Zhang, D. Patel, Y. Nan, and S. Fan: Inhibition of Early Lytic Genes of Kaposi’s Sarcoma-Associated Herpesvirus by Antiviral Morpholino Oligomers Leads to Engraftment Suppression of Primary Effusion Lymphoma in SCID Mice. Antiviral Therapy 2011; 16:657-66. PMID: 21817187.
  • T. Opriessnig, D. Patel, R. Wang, P.G. Halbur, X-J. Meng, D.A. Stein, and Y. Zhang: Inhibition of Porcine Reproductive and Respiratory Syndrome Virus Infection in Piglets by a Peptide-conjugated Morpholino Oligomer. Antiviral Research 2011; 9:36-42. PMID: 21554902.
  • D. Patel, Y. Nan, M. Shen, X. Zhu, and Y. Zhang: Porcine Reproductive and Respiratory Syndrome Virus Inhibits Type I IFN Signaling by Blocking STAT1/STAT2 Nuclear Translocation. Journal of Virology 2010; 84:21:11045-55. Pubmed PMID: 20739522.
  • D. Patel, D.A. Stein, and Y. Zhang: Morpholino Oligomer-Mediated Protection of Porcine Pulmonary Alveolar Macrophages from Arterivirus-Induced Cell Death. Antiviral Therapy 2009; 14:899-909. Pubmed PMID: 19918094
  • H. Kannan, S. Fan, D. Patel, I. Bossis, and Y. Zhang: The Hepatitis E Virus ORF3 Product Interacts with Microtubules and Interferes with Their Dynamics. Journal of Virology 2009; 83(13):6375-6382. Pubmed PMID: 19369329.
  • X. Han, S. Fan, D. Patel, and Y. Zhang: Enhanced Inhibitory Effect on PRRSV Replication by Combination of Two Morpholino oligomers. Antiviral Research 2009; 82:59-66. PMID: 19428596.
  • D. Patel, T. Opriessnig, D.A. Stein, P.G. Halbur, X-J. Meng, P.L. Iversen, and Y. Zhang: Peptide-conjugated Morpholino Oligomers Inhibit Porcine Reproductive and Respiratory Syndrome Virus Replication. Antiviral Research 2008; 77:95-107. PMID: 17959259.
  • Y. Zhang, R. Watkins, D. Patel, D. Stein, P. Iversen: Blockade of Viral Interleukin 6 Expression of Kaposi’s Sarcoma-Associated Herpesvirus. Molecular Cancer Therapeutics 2008; 7(3):712-20. PMID: 18347156.
  • Y. Zhang, K. Wang, D. Stein, D. Patel, R. Watkins, P. Iversen, D.O. Matson: Inhibition of Replication and Transcription Activator and Latency-Associated Nuclear Antigen of Kaposi’s Sarcoma-Associated Herpesvirus by Morpholino Antisense Oligomers. Antiviral Research 2007; 73:12-23. PMID: 16842866.
  • Z. Zhang, D.K. Mitchell, C. Afflerbach, Y. Zhang and D.O. Matson. Quantitation of Human Astrovirus by Real-time Reverse- Transcription-Polymerase Chain Reaction to Examine Correlation with Clinical Illness. Journal of Virological Methods 2006; 134:190-196. PMID: 16490263.
  • Y. Zhang, D. Stein, S. Fan, K. Wang, A.D. Kroeker, X-J. Meng, Patrick Iversen, David O. Matson: Suppression of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Replication by Morpholino Antisense Oligomers. Veterinary Microbiology 2006; 117:117-129. PMID: 16839712.

 

Above: Sub-cellular distribution of vp13 in HeLa Cells

 

 

 

 

 

 

Below:PRRSV Virion

 

 

 

 

 

 

 

 

 

 

 





 

 

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