Jaekeun Park, D.V.M., Ph.D.
Assistant Professor. Email: jpark138@umd.edu , Phone: +1-301-314-0687
Education
2020 - 2022 Research fellow
National Institute of Allergy and Infectious Diseases, National Institutes of Health - Maryland, USA
2015 – 2020 Post-doctoral fellow
National Institute of Allergy and Infectious Diseases, National Institutes of Health - Maryland, USA
2010 - 2014 Ph.D., Veterinary Microbiology and Infectious Diseases, Konkuk University - Seoul, S. Korea
2002 - 2010 B.S., D.V.M., Veterinary Medicine, Konkuk University - Seoul, South Korea
Professional Experience
2022 - present: Assistant Professor, Department of Veterinary Medicine, Virginia-Maryland School of Veterinary Medicine, University of Maryland, College Park, MD
Research Interest
Influenza is one of the most significant causes of global mortality. Seasonal influenza epidemics have resulted in 80,000 or more annual deaths in the United States alone. Moreover, four global influenza pandemics in the past century—1918, 1957, 1968, and 2009—resulted in tens of millions of cumulative deaths. While current influenza vaccines have contributed significantly to the control of influenza, no highly efficacious influenza vaccines that are broadly and durably protective have yet been developed due to critical gaps in knowledge, including 1) incomplete understanding of immune correlates of protection, leading to 2) lack of effective vaccine strategies to induce broad and durable protection, and 3) imperfect animal models in which to evaluate vaccine efficacy.
To fill the gap in knowledge, we focus on 1) defining molecular signatures of protective or pathological lung resident memory T (TRM) cells, 2) identifying strategies for robust generation and maintenance of protective lung TRM cells, and 3) advancing current influenza animal models to reliably support influenza research on viral pathogenesis and vaccine development. Findings from the above research areas are expected to provide key insights concerning the protective or pathological mucosal immune responses to influenza viruses and help identify effective therapeutic and vaccine interventions against influenza and other zoonotic respiratory viruses.
Publications
1. J. Park et al., An inactivated multivalent influenza A virus vaccine is broadly protective in mice and ferrets. (2022, Accepted in Sci Transl Med)
2. F. D'Agnillo, K. A. Walters, Y. Xiao, Z. M. Sheng, K. Scherler, J. Park, S. Gygli, L. A. Rosas, K. Sadtler, H. Kalish, C. A. Blatti, 3rd, R. Zhu, L. Gatzke, C. Bushell, M. J. Memoli, S. J. O'Day, T. D. Fischer, T. C. Hammond, R. C. Lee, J. C. Cash, M. E. Powers, G. E. O'Keefe, K. J. Butnor, A. V. Rapkiewicz, W.
3. D. Travis, S. P. Layne, J. C. Kash, J. K. Taubenberger, Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19. Sci Transl Med, eabj7790 (2021).
4. L. T. Giurgea, J. K. Park, K. A. Walters, K. Scherler, A. Cervantes-Medina, A. Freeman, L. A. Rosas, J. C. Kash, J. K. Taubenberger, M. J. Memoli, The effect of calcium and magnesium on activity, immunogenicity, and efficacy of a recombinant N1/N2 neuraminidase vaccine. NPJ Vaccines 6, 48 (2021).
5. J. K. Park, Y. Xiao, M. D. Ramuta, L. A. Rosas, S. Fong, A. M. Matthews, A. D. Freeman, M. A. Gouzoulis, N. A. Batchenkova, X. Yang, K. Scherler, L. Qi, S. Reed, R. Athota, L. Czajkowski, A. Han, D. M. Morens, K. A. Walters, M. J. Memoli, J. C. Kash, J. K. Taubenberger, Pre-existing immunity to influenza virus hemagglutinin stalk might drive selection for antibody-escape mutant viruses in a human challenge model. Nat Med 26, 1240-1246 (2020).
6. M. J. Memoli, A. Han, K. A. Walters, L. Czajkowski, S. Reed, R. Athota, L. Angela Rosas, A. Cervantes-Medina, J. K. Park, D. M. Morens, J. C. Kash, J. K. Taubenberger, Influenza A Reinfection in Sequential Human Challenge: Implications for Protective Immunity and "Universal" Vaccine Development. Clin Infect Dis 70, 748-753 (2020).
7. Y. Xiao, J. K. Park, S. Williams, M. Ramuta, A. Cervantes-Medina, T. Bristol, S. Smith, L. Czajkowski, A. Han, J. C. Kash, M. J. Memoli, J. K. Taubenberger, Deep sequencing of 2009 influenza A/H1N1 virus isolated from volunteer human challenge study participants and natural infections. Virology 534, 96-107 (2019).
8. K. A. Walters, R. Zhu, M. Welge, K. Scherler, J. K. Park, Z. Rahil, H. Wang, L. Auvil, C. Bushell, M. Y. Lee, D. Baxter, T. Bristol, L. A. Rosas, A. Cervantes-Medina, L. Czajkowski, A. Han, M. J. Memoli, J. K. Taubenberger, J. C. Kash, Differential Effects of Influenza Virus NA, HA Head, and HA Stalk Antibodies on Peripheral Blood Leukocyte Gene Expression during Human Infection. MBio 10, (2019).
9. J. K. Park, A. Han, L. Czajkowski, S. Reed, R. Athota, T. Bristol, L. A. Rosas, A. Cervantes-Medina, J. K. Taubenberger, M. J. Memoli, Evaluation of Preexisting Anti-Hemagglutinin Stalk Antibody as a Correlate of Protection in a Healthy Volunteer Challenge with Influenza A/H1N1pdm Virus. MBio 9, (2018).
10. J. H. Shin, J. Y. Noh, K. H. Kim, J. K. Park, J. H. Lee, S. D. Jeong, D. Y. Jung, C. S. Song, Y. C. Kim, Effect of zymosan and poly (I:C) adjuvants on responses to microneedle immunization coated with whole inactivated influenza vaccine. J Control Release 265, 83-92 (2017).
11. S. S. Yuk, D. H. Lee, J. K. Park, E. O. Tseren-Ochir, J. H. Kwon, J. Y. Noh, C. S. Song, Experimental infection of dogs with highly pathogenic avian influenza virus (H5N8). J Vet Sci 18, 381-384 (2017).
12. J. K. Park, J. K. Taubenberger, Universal Influenza Vaccines: To Dream the Possible Dream? ACS Infect Dis 2, 5-7 (2016).
A complete publication list can be found at:
https://www.ncbi.nlm.nih.gov/myncbi/1dwr2dljshLY_w/bibliography/public/
