Meiqing Shi DVM, Ph.D.
Biography
Dr. Shi received his D.V.M. from Hunan Agricultural University and M.S. from South China Agricultural University in China. After he got his M.S. degree, he worked as a Teaching Assistant and later a Lecturer at the College of Veterinary Medicine, South China Agricultural University for 7 years. Then he went to Germany for PhD training and received his PhD degree in parasite immunology from Faculty of Veterinary Medicine, Justus Liebig University of Giessen. He did postdoc training in parasite and fungal immunology at University of Saskatchewan and University of Calgary in Canada. In 2011, he joined the Department of Veterinary Medicine, University of Maryland College Park as Assistant Professor and promoted to Associate Professor in 2017.
Research interest
The area of interest in Dr. Shi’s lab is host-pathogen interactions, with special interest in the intravascular immune responses to Cryptococcus neoformans and Trypanosoma brucei, as well as their transmigration into the brain across the blood-brain barrier. Both pathogens can survive in the bloodstream and invade the brain, causing brain infections. His lab has developed a mouse model system based on intravital microscopy to study the dynamic interactions of host cells with the pathogens in living hosts. The long-term goal of his lab is to understand how the pathogens evade immune responses and cause infections.
Publications
● Sun D, Sun P, Li H, Zhang M, Liu G, Strickland AB, Chen Y, Fu Y, Xu J, Yosri M, Nan Y, Zhou H, Zhang X, Shi M. 2019. Fungal dissemination is limited by liver macrophage filtration of the blood. Nature Communications. In press.
Shi M, Mody CH. 2016. Fungal infection in the brain: What we learned from intravital imaging. Frontiers in Immunology 7:292.
● Sun D, Shi M. 2016. Neutrophil swarming toward Cryptococcus neoformans is mediated by complement and leukotriene B4. Biochemical and Biophysical Research Communications 477:945-951.
● Sun D, Zhang M, Liu G, Wu H, Li C, Zhou H, Zhang X, Shi M. 2016. Intravascular clearance of disseminating Cryptococcus neoformans in the brain can be improved by enhancing neutrophil recruitment in mice. European Journal of Immunology 46:1704-1714.
● Zhang M, Sun D, Liu G, Wu H, Zhou H, Shi M. 2016. Real-time in vivo imaging reveals the ability of neutrophils to remove Cryptococcus neoformans directly from the brain vasculature. Journal of Leukocyte Biology 99:467-473.
● Sun D, Zhang M, Liu G, Wu H, Zhu X, Zhou H, Shi M. 2016. Real-time imaging of interactions of neutrophils with Cryptococcus neoformans demonstrates a crucial role of C5a-C5aR signaling. Infection and Immunity 84:216-229.
● Liu G, Xu J, Wu H, Sun D, Zhang X, Zhu X, Magez S, Shi M. 2015. IL-27 signaling is crucial for survival of mice infected with African trypanosomes via preventing lethal effects of CD4+ T cells and IFN-γ. PLOS Pathogens 11:e1005065.
● Liu G, Sun D, Wu H, Zhang M, Huan H, Xu J, Zhang X, Zhou H, Shi M. 2015. Distinct contributions of CD4+ and CD8+ T cells to pathogenesis of Trypanosoma brucei infection in the context of gamma interferon and Interleukin-10. Infection and Immunity 83:2785-2795.
● Li SS, Kyei SK, Timm-Mccann M, Ogbomo H, Jones GJ, Shi M, Xiang R, Oykhman P, Huston SM, Islam A, Gill MJ, Robbins SM, Mody CH. 2013. Identification of the NK receptor for direct fungal recognition and cytotoxicity that is defective in HIV-infected patients but restored using IL-12. Cell Host & Microbe 14:387-397.
